The BAZ2A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to BAZ2A, TIP5, and WALp3. This antibody recognizes Human antigen. The BAZ2A Antibody has been validated for the following applications: Western Blot.
Description
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.Jones M.H., Genomics 63:40-45(2000).Bechtel S., BMC Genomics 8:399-399(2007).Scherer S.E., Nature 440:346-351(2006)